Bay Area COVID Patients Mark ‘Paxlovid Rebound’ After Antiviral Treatment

When Berkeley resident Myriam Misrach tested positive for the coronavirus last month, she started taking the antiviral pill Paxlovid the same day. During the five-day course of treatment, her cough and shortness of breath usually subsided, but a few days after she took the last pill, her symptoms returned.

48 hours later, she also had a fever, headache, nausea, a runny nose and lost her sense of taste, she said. And she tested positive for the virus again — despite testing negative and feeling much better a few days earlier.

“I had everything in the book,” said Misrach, 66, who has been vaccinated and boosted. “It was not a mild case at all.”

Misrach continued to test positive for two weeks after that and is still coughing today, although the other symptoms have disappeared. What was even more puzzling, she said, was that her husband had just taken Paxlovid and it “worked beautifully” for him — he started feeling better almost immediately and stayed that way, though he, too, tested positive after initially testing negative.

“I don’t blame Paxlovid, but I think they should study it more,” she said.

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