Brain hemorrhages in babies’ first year can lead to long-term vision problems

Overview: Babies who experience severe brain hemorrhages during their first year of life are more likely to have long-term visual problems, a new study reports.

Source: University of Bristol

Severe “brain bleeding” experienced by some babies in the first year after birth leads to long-term vision problems, researchers at the University of Bristol found as part of a 10-year follow-up study.

The study, published in the journal Developmental Medicine and Pediatric Neurology Today [23 June]assessed 32 children who had detailed assessments at 10 to 11 years of age after experiencing grade 3 or 4 intraventricular hemorrhage (cerebral hemorrhage) and ventricular dilation (IVHVD) as part of a study called DRIFT10.

The DRIFT10 study was set up to investigate a “brainwashing” technique for brain haemorrhage called DRIFT (Drainage, Irrigation and Fibrinolytic Therapy). Developed by Bristol researchers, DRIFT is the first and only treatment that objectively benefits infants with severe brain haemorrhage by flushing out the ventricles in the brain to remove toxic fluid and reduce pressure.

The research team assessed 32 children, ages 10 to 11 years old. They examined whether the degree of IVHVD that infants experienced influenced their visual outcome at the end of their elementary school years and examined associations between visual outcomes with cognitive outcomes and with additional support at school.

The visual exams were part of a 10-year follow-up study for children in the original DRIFT randomized study. The testers followed a protocol and it was not known to them whether the child had experienced grade 3 or grade 4 IVHVD and any other data.

The study found that all 32 children assessed had at least one visual impairment. The mean number of disabilities per child was six for children who had a grade 4 IVHVD compared with three for children who had a grade 3 IVHVD. Each additional visual impairment for each child was associated with greater educational support at school, after adjusting for developmental age equivalence.

These vision problems in the children ten years later were often due to damage to the visual areas in the brain. These include difficulty moving the eyes accurately, detecting objects in the space around them, or having visually matching shapes or orientations of lines.

e 10-year follow-up of visual functions in 32 children who had grade 3 or grade 4 intraventricular hemorrhage with ventricular dilatation (IVHVD) in the first year after birth. Credit: University of Bristol

The children’s parents were not aware of these problems and usually indicated that their children could see normally as long as they wore glasses.

However, the researchers found that for every additional vision problem a child had, they were more likely to receive additional support in their learning. This suggests that the vision problems may have contributed to the learning difficulties of this group of children.

Cathy Williams, lead author of the study and Professor of Pediatric Ophthalmology at Bristol Medical School: Population Health Sciences and Consultant Pediatric Ophthalmologist at University Hospitals Bristol and Weston NHS Foundation Trust (UHBW), explains: “Our research suggests that all children who experience cerebral haemorrhage or similar problems, as babies must undergo eye tests to identify brain-related vision problems as they grow up so that appropriate support can be provided to see if it is helpful for them.

“In the future, researchers should be aware that parents who report normal vision may miss vision problems important to their children’s learning and development.”

About this news about neurodevelopment and visual neuroscience

Author: press office
Source: University of Bristol
Contact: Press Office – University of Bristol
Image: The image is attributed to the University of Bristol

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Original research: Open access.
“Vision function in children 10 years after grade 3 or 4 intraventricular hemorrhage with ventricular dilation: a masked prospective study” by Cathy Williams et al. Developmental Medicine and Pediatric Neurology


Abstract

Visual function in children 10 years after grade 3 or 4 intraventricular hemorrhage with ventricular dilation: a masked prospective study

Goal

We examined children 10 to 11 years after grade 3 or 4 intraventricular hemorrhage and ventricular dilation (IVHVD) and examined whether the grade of IVHVD affected their visual outcome. We examined associations between visual outcomes with cognitive outcomes and additional support at school.

Method

The visual examinations were part of a 10-year follow-up study for children in a randomized trial. Testers followed a protocol and were masked to see if the child had experienced grade 3 or grade 4 IVHVD and any other data.

Results

Thirty-two children were tested: 24 were male and the mean (standard deviation) age was 10 years 5 months (1 year 2 months); range 8 years 9 months to 12 years 9 months. All had at least one visual impairment. The median (interquartile range) number of disabilities per child was six (six to nine) for children who had a Grade 4 IVHVD compared with three (two to four) for children who had a Grade 3 IVHVD (p = 0.003). Each additional visual impairment per child was associated with more educational support at school, after adjusting for developmental age equivalence (odds ratio = 1.7 [95% confidence interval 1.1–2.6]† p = 0.015).

Interpretation

Children who experience grade 3 or 4 IVHVD have a high degree of visual morbidity by the ages of 10 to 11 years. These children may have unmet visual needs and their results could improve if these needs could be met.

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