The Bureau of Meteorology (BOM) has warned that winds can peak at 100 km/h and reach 110 km/h over elevated areas.
Strongest winds are expected this afternoon and persist into Wednesday morning.
The agency said a strong cold front will move into the west of the state late today, triggering a “strong north-westerly current.”
There is also a chance of showers and thunderstorms in the affected areas.
There is now a Watch and Act warning for residents to “prepare to take shelter” for the Central Highlands, Dandenong, Great Dividing Range.
Severe weather warnings apply to areas such as Stawell, Hamilton, Warrnambool, Portland, Maryborough, Castlemaine, Kyneton, Ballarat, Frankston, Bacchus Marsh, Bright and Falls Creek.
Victorians urged to “prepare now”
The state emergency service has urged affected residents to “prepare now” for the wild conditions.
VICSES Chief Officer Operations Tim Wiebusch said it is important that residents remain vigilant.
“Our volunteers across the state are ready to help communities with the severe weather forecast for tonight,” he said.
“But with winds potentially damaging to destructive, it’s vital that you remain vigilant and up-to-date with the latest warnings and advice.”
“Be sure to heed the advice of emergency services and secure loose items in and around your home, park your vehicle under cover, away from trees and stay indoors until the storm passes.”
‘River City’ wakes up as the fog devours the city
Wiebusch said residents should ensure that gutters, downspouts and drains are not blocked to cope with the potential of heavy rainfall.
Tomorrow there is a high chance of showers in Melbourne and a chance of a thunderstorm.
Temperatures are forecast to rise above 19 degrees.
Call 132 500 for emergency assistance from VICSES.